Supporting our cytochrome c assays, we confirmed no change in mitochondrial outer membrane permeabilization (MOMP) in cells surviving 5FU treatment (compared to the dimethyl sulfoxide group), and no increase in mitochondrial apoptotic priming based on BH3-profiling 15,16 induced by 5FU treatment (Extended Data Fig
Furthermore, it may alter the transcript levels of genes involved in oogenesis, folliculogenesis, and embryonic development 12 and impair nuclear and cytoplasmic maturation events such as the translocation of cortical granules and cytoskeletal rearrangement 13 , which can eventually lead to apoptosis 14
Available online at: (Accessed April 14, 2025)
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Safety and efficacy of melatonin in pediatric migraine prophylaxis