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The C-terminal amidation is critical for full biological activity, as the free-acid form shows significantly reduced receptor binding

Because a reduction of glutathione levels in cells has been found to increase the risks for diseases and poisoning, direct intravenous injection of glutathione has been used to treat patients with chronic liver diseases and poisoning [8, 9]

Conversely, serum levels of lipid markers associated with oxidative stress are elevated, including reactive oxygen species (ROS) and nitrogen species (NS), such as malondialdehyde (MDA), Malondialdehyde (MDA), nitric oxide (NO) and nitric oxide synthase (NOS) (Moylan et al., 2014

Dietary Sources The body synthesizes glutathione endogenously, so dietary intake is supplementary rather than essential

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