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Neither is accessible to Medicare or Medicaid patients, and neither functions as a standalone discount for fully uninsured individuals

The choice between metformin and GLP-1s, or any other blood sugar lowering medication, should be made based on individual factors, including the patient's medical history, lifestyle, treatment goals, and potential side effects

For semaglutide specifically, patients with kidney dysfunction do not require renal dosing adjustments (Key Considerations in Use of SGLT2 Inhibitors and GLP-1RAs for CV Risk Reduction in Patients with T2D, 2020) Contraindications to GLP-1 agonists include a history of serious hypersensitivity reactions to a GLP-1 agonist, pregnancy, breastfeeding, and a personal or family history of medullary or thyroid cancer or MEN2 (Key Considerations in Use of SGLT2 Inhibitors and GLP-1RAs for CV Risk Reduction in Patients with T2D, 2020)

It is a potent antioxidant and has been shown to support the body's immune system.*

Between the start of fiscal year 2024 and the end of fiscal year 2025, GLP-1 costs roughly quadrupled in Rhode Island Medicaids per-member monthly payments to its managed care plans, according to the department

Fourth, intertrial heterogeneity existed across the studies on HbA1c change