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Chapter 14

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In addition to the effect on metabolism of acetaminophen, these antiepileptics may also increase the formation of the hepatotoxic metabolite N-acetyl-p-benzoquinone (NAPQI), which increases the risk of hepatotoxicity by exceeding glutathione binding capacity

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Aunque el mecanismo de accin no es completamente conocido, pudiendo verse implicados mecanismos relacionados con los receptores de GLP-1 y GIP, los resultados iniciales muestran perspectivas alentadoras en el tratamiento de la obesidad

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The primary endpoint is a renal composite episode defined by a decrease in GFR 50%, end-stage renal failure, and death from a renal-cause or cardiovascular-caused death, and it is scheduled for completion in 2024

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