MIF null mice are entirely resistant to the detrimental effects of OVX, implying that MIF acts as a key downstream mediator of both the detrimental effects of estrogen deficiency and the beneficial effects of estrogen replacement on skin wound healing [57, 175, 182]
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11 have shown the efficacy of NACA against L-buthionine-(S,R) sulfoximine (BSO, a glutathione synthesis inhibitor)- induced cataract in wistar rat pups
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HIV-infected adults in one study were given 300 mg of alpha-lipoic acid three times daily for six months, which resulted in significant elevations in total glutathione [58]