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A key driver of this process is insulin resistance, which affects both hepatic and peripheral tissues, creating a metabolic environment that simultaneously promotes hyperglycemia and hepatic steatosis through selective pathway activation
Body composition changes become visible at months 2 to 3 with consistent training and dietary support
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There also is a tangled web of medical and social factors surrounding obesity, all of which are shadowed by persistent stigma around weight
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doi:10.1136/bmjopen-2023-083550 Dumolt JH, Rosario FJ, Kramer AC, Horwitz S, Powell TL, Jansson T
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