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Transketolases require thiamine pyrophosphate (TPP), vitamin B1, for proper function

However, recent studies have suggested that sirtuin reactivity and the site selectivity may differ between nucleosomal and non-nucleosomal substrates 15,16

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Improvements in sleep, hot flashes, energy, or mood may begin within a few weeks

Headache Nausea Vomiting Diarrhea Fatigue or weakness Tingling sensation in hands and feet 5