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The FGF19 subfamily of FGFs, consisting of FGF19, FGF21, and FGF23, is characterized by reduced affinity for heparan sulfate (HS) ( via the systemic circulation, as well as canonical FGF paracrine signaling on their cell of origin or nearby cells (48), significant differences exists between them, primarily in the ability of FGF19 to stimulate hepatocyte proliferation and to suppress bile acid synthesis (49)

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