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Evaluation of AR-H067637, the active metabolite of the new direct thrombin inhibitor AZD0837, in models of venous and arterial thrombosis and bleeding in anaesthetised rats
Study population We included all patients registered as having type 2 diabetes in the National Diabetes Register who filled their first prescription for a GLP-1 receptor agonist, and, in a separate cohort, all patients registered as having type 2 diabetes in the National Diabetes Register who filled their first prescription for an SGLT2 inhibitor, between 1 January 2017 and 31 December 2021 (ensuring a minimum of 1-year follow-up until the end of the study period on 31 December 2022)
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Core safety evaluations typically encompass strain identification and characterization, pathogenicity and toxicity assessment, and contaminant screening (160)
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