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While a single 5-mg dose pharmacokinetic study cannot provide long-term data, results from phase III studies consistently showed decreases in mean alanine transaminase and aspartate transaminase values in people with T2D treated with tirzepatide (mean percent changes from baseline ranged from 12 to 33% for alanine transaminase and 1 to 16% for aspartate transaminase) [9,10,11,12,13]

This pattern appears so consistently that providers who regularly manage these transitions now warn patients in advance

Gastrointestinal Symptoms Nausea is the most frequently reported side effect

Adeva-Andany, M

Feng, X.M