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Furthermore, the weight loss induced by tirzepatide appears to be primarily due to a greater reduction in fat mass compared to metabolically active lean mass, resulting in a favorable redistribution of abdominal ectopic adipose tissue and a marked reduction in waist circumference and intrahepatic fat [54]

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This is a different approach and the early outcomes being studied are strong enough to make experts curious about whether the triple mechanism can translate into meaningful real-world benefits once larger trials confirm safety and long-term results

Dysfunction of the HPA axis can synergistically lead to various stress-dependent diseases through neural, immune, and endocrine pathways (60, 61)

In severe cases, you may need to take off for a day due to swelling or itching