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Complex naturally present in human plasma, studied on matrix remodeling and skin regeneration for 50 years

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Weckerle J, Picart-Armada S, Klee S, Bretschneider T, Luippold AH, Rist W, et al

Curr Pharm Des 20:11211125 Shibuya M (2011) Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies