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We do now have drugs (Dononamab and Lecanemab) which show some benefit and one might consider whether these should be the placebo treatments against which new drugs are tested. Prof Paresh Malhotra , Group Leader at the UK Dementia Research Institute Care Research & Technology Centre and Head of the Division of Neurology at Imperial College London said: "These two linked trials show that, unfortunately, semaglutide appears to have no effect on progression in people with established Alzheimers disease, including people who have evidence of some damage to brain blood vessels

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Reducing the accumulation of lactic acid and increasing the lactate threshold reduces fatigue levels and your muscles will be less acidic and sore

They reduce hyperglycemia and sequentially inhibit glucotoxicity-mediated inflammation, such as endothelial dysfunction and oxidative stress

It is a common side effect, especially for first-time users