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acts centrally to reduce appetite Setmelanotide : Reserved for specific genetic obesity syndromes (e.g., POMC/PCSK1/LEPR deficiency, Bardet-Biedl syndrome) under specialist supervision Non-pharmacological interventions form the cornerstone of weight management and may be particularly appropriate: Structured lifestyle programmes : NICE recommends multicomponent interventions including dietary modification, increased physical activity, and behavioural strategies
Note that tirzepatide is not recommended for patients with severe gastroparesis
Why this matters for safety: Melanoma arises from melanocytes
Following the use of GLP-1 agonists, patients may also present with symptoms warranting further targeted imaging evaluation
The lip tissue, thinner and more exposed than the rest of the face, is particularly vulnerable to pigmentary changes, and those changes can come from very different sources
