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van den Heuvel JM, Farzan N, van Hoek M, Maitland-van der Zee A-H, Ahmadizar F
24.2% weight loss at 48 weeks This figure from the NEJM 2023 Phase 2 trial is the most-cited data point for Retatrutide
Others reported before us that exenatide or GLP-1 increased FOC in HAP (Wallner et al
many general practices stopped treatment
5-Amino-1MQ stops that waste step
Suggested macro split (lean bulk or recomp): Protein: 1.01.2g per lb of body weight Carbs: 1.52.5g per lb (higher on training days) Fats: 0.30.4g per lb (favor omega-3 and monounsaturated sources) Adequate carbohydrate intake is essential to fuel IGF-1-mediated muscle growth and recovery by supporting insulin sensitivity and glycogen replenishment. Tipton & Wolfe, Journal of Sports Sciences Nutrient Timing Pre-Workout: Complex carbs + fast-digesting protein Post-Workout (with IGF-1 LR3): High-glycemic carbs + Collagen Protein or whey to maximize amino acid delivery Before Bed: GH-supportive stack (e.g., ZMT + Krill Oil) to support overnight repair Training Protocol Recommendations Because IGF-1 LR3 enhances recovery and cellular growth , it works best in high-volume hypertrophy or recomposition training blocks
