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UK Summaries of Product Characteristics (SmPCs) advise caution in people with a history of pancreatitis, severe gastrointestinal disease, or thyroid disease

These technologies reduce daily management burden, but access remains a major issue

Additionally, patients should be aware of symptoms of hypothyroidism such as fatigue, weight gain, and depression, and report any changes to their healthcare provider

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These safety assessments must unequivocally demonstrate that genetically modified organisms cannot persist in the environment, lack transferable antibiotic resistance markers, and are incapable of disseminating any deleterious genetic material to other microbiota (99)

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