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A 2022 JAMA meta-analysis of GLP-1 receptor agonists confirmed an increased risk of biliary disease with this medication class
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Multiple meta-analyses further revealed this complexity: A meta-analysis on the body component modification effect of GLP-1 receptor agonists showed that compared with the control group, GLP-1RA users not only had a significant reduction in fat body mass, but also a more obvious reduction in lean body mass (weighted mean difference was 1.02 kg) [55]
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