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A specific flavonoid in hops xanthohumol helps iodide uptake by thyroid cells, boosting thyroid hormone production

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by binding to Apaf-1, HSP70 induces conformational changes that mask the procaspase-9-binding site on Apaf-1, thereby preventing procaspase-9 recruitment to the apoptosome and inhibiting downstream caspase activation (Beere et al., 2000)