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The 6.6 percentage-point gain from adding cagrilintide to semaglutide is the cleanest existing read on what amylin layering buys you on top of an incretin agonist
doi:10.1038/s41598-024-65310-y Neelakantan H, Hommel JD, Watowich SJ, et al
This is because both compounds affect gastrointestinal motility and appetite through their respective mechanisms, and layering them too aggressively creates compounding GI effects that can derail compliance
Archived from the original on 12 August 2025
Such effects could be related to pain-modulating properties observed with GH in other studies
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