Spinal fusion procedures: Surgical joining of vertebrae treating instability, deformity, or severe degeneration
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The excitatory effect of exendin-4 was blocked by GLP-1 receptor antagonist 1 (compound 5 d) (1015 min pretreatment of antagonist followed by 100 nM exendin-4 plus antagonist, n = 7) (Fig
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Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels