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GLP-1 preadministration 30 min before ghrelin administration to rats and mice abolished ghrelin-induced food intake, while ghrelin preadministration abolished the anorectic effect of GLP-1
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A sluggish thyroid reduces fat-burning efficiency, while chronic stress elevates cortisol levels , leading to excess abdominal fat
Therefore, targeting specific enzymesubstrate pairs will be a key future research direction
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