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Michael Conlon describe the scope of it: In clinical trials, CagriSema has achieved greater effects than either component [cagrilintide or semaglutide] alone
Tesson, A
A review of pivotal clinical trials for semaglutide (STEP, SUSTAIN), dulaglutide (REWIND), liraglutide (LEADER), and tirzepatide (SURPASS, SURMOUNT) does not identify muscle cramps as occurring at significantly higher rates compared to placebo groups
This means that doctors are prescribing the drug off-label, presumably for another condition, such as weight loss
Increasing growth hormone by significant amounts has been shown in some animal studies to reduce life span by up to 50%, while reducing levels has been shown to boost life span by up to 33%
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