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PubMed Link Bilski R, et al

This analysis identified six primary substratesperoxiredoxin-4 (PRDX4), GRB10-interacting GYF protein 2 (GGYF2), ubiquitin-like-conjugating enzyme ATG3 (ATG3), RNA-binding protein 33 (RBM33), heterogeneous nuclear ribonucleoprotein K (HNRPK) and galactokinase (GALK1)with a greater than one log 2 fold change (log 2 FC) enrichment ( P 1, P 1), it did not reach statistical significance ( P = 0.22

4) collectively regulate biological processes in human malignancies and are associated with the proliferation, invasion and therapeutic resistance of cancer cells [94]

*J Orthop Res.* 24(5):982-989

Oxidative and electrophilic stress basically modify the cysteine residues state of Keap-1 causes a conformational change and Nrf2 release