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Evidence grades assigned using GRADE principles

From SURMOUNT-1 reanalysis at week 4: 2.5 mg arm: average weight change -1.2% (about 2.5 lb for a 200 lb starting weight) 5 mg arm: average weight change -2.1% (about 4.2 lb) 10 mg arm: average weight change -2.6% (about 5.2 lb) 15 mg arm: average weight change -2.9% (about 5.8 lb) Placebo arm: average weight change -0.4% The headline 21% weight loss number from SURMOUNT-1 is the 72-week result at 15 mg

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Anti-Cancer Properties Hydroxytyrosol shows a variety of pharmacological activities such as antioxidant properties, anticancer, anti-inflammatory, and neuroprotective activities, with its anti-cancer effects being particularly noteworthy: DNA Protection: Several studies have shown that hydroxytyrosol is capable of scavenging peroxynitrite, thereby preventing DNA damage and nitration of protein tyrosine residues, which helps maintain genetic integrity and reduces cancer risk

Month 2: Stepping Up (0.5 mg) After four weeks of 0.25 mg, the dose usually doubles to 0.5 mg