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Its reduced IGFBP affinity makes it a preferred tool for distinguishing receptor-mediated effects from binding-protein-mediated sequestration
Previous work has shown that the abundance of Lactobacillus reuteri (normalized to a control group) decreases during the onset of obesity and remains suppressed even after dieting in mice 99 , which parallels our observations that vehicle-treated diet-switched mice had lower levels of Lactobacillus than the 5A-1MQ-treated mice, the latter of which also demonstrated greater weight loss
10.1093/jnen/60.6.621 54 TalapkoJ.MetroviT.JuzbaiM.TomasM.EriS.Horvat AleksijeviL.et al
Since B12 is water-soluble, excess amounts are excreted through urine rather than stored in the body, reducing the risk of toxicity
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