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2.1 Misfolding and aggregation of proteins In many neurodegenerative diseases, the accumulation of proteins that are misfolded plays a critical role in disease progression

Reconstitution experiments with different buffer components suggested that the blue pigment was an iron co-pigment of the quinoidal base anion form of cyanidin ( 8 -AM) (Extended Data Fig

Link Sikiric P, et al

This mixture was left on ice for 5 min before addition of neutralization buffer (final concentration, 0.17 mM ammonium carbonate (5330050050) in LCMS-grade H 2 O) and gently mixed before being incubated on dry ice for 15 min

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