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Additionally, given the frequent occurrence of spleen enlargement in psoriasis due to inflammation, immune overactivation, and metabolic syndrome, spleen analysis post-euthanasia revealed that group V significantly reduced spleen weight to 82.5 mg compared to splenomegaly (169 mg) of group I (PBS) (Supplementary Fig

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4), suggesting that, similar to Munc13-4-deficient cells 37 , ENDO3 decreases endosomal vesicle dynamics