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This SC layer forms the principal barrier to drug permeation, largely due to its unique lipid composition, predominantly ceramides, cholesterol, fatty acids, and cholesteryl sulfate, arranged in bilayer structures within intercellular spaces [48, 223,224,225]

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Endoscopy (2009) 41:10829

Resveratrol Prevents Insulin Resistance Caused by Short-Term Elevation of Free Fatty Acids In Vivo