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Risks of Rapid Dose Escalation Speeding up dose escalation may seem beneficial at first, especially when patients experience quick weight loss or improved glucose control with GLP-1 therapy
In individuals struggling with excess weight or obesity, these hormonal responses are thought to be impaired
NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential
Pediatrics 1969;43:463-5
However, this phenomenon is rather a restoration of the first-phase insulin response due to the concomitant weight loss of typically 56 kg
Factors that may contribute to non-response include extremely chronic structural degeneration, product quality issues, improper storage or reconstitution, or individual variations in peptide metabolism
