What the Injection Contains A typical compounded weekly dose includes semaglutide titrated from 0.25 milligrams up to 2.4 milligrams over 16 to 20 weeks, plus 1,000 micrograms of methylcobalamin
Periodontal EDS (pEDS) is characterized by severe and intractable periodontitis of early onset (childhood or adolescence), lack of attached gingiva, pretibial plaques, and family history of a first-degree relative who meets clinical criteria Cardiac-valvular EDS (cvEDS) is characterized by severe progressive cardiac-valvular problems (aortic valve, mitral valve), skin problems (hyperextensibility, atrophic scars, thin skin, easy bruising), and joint hypermobility (generalized or restricted to small joints)
Your clinician will confirm the exact dose, schedule, and injection locations for your body and goals
It is important to note that while both peptides have been extensively studied individually in preclinical models, published research specifically examining the two compounds used together in a single study is limited
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PMCID: PMC1863555