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A solution that remains hazy after adequate time to fully dissolve, or that develops visible particles after a period in storage, should not be used in an active protocol

Without intrinsic factor, the small intestine cannot efficiently absorb dietary B12 through the normal receptor-mediated pathway

Intramuscular therapy leads to more rapid improvement and should be considered in patients with severe deficiency or severe neurologic symptoms

Reconstituting once produces a single solution from which every daily draw is taken

after reconstitution, refrigerate at 28 C (35.646.4 F) for up to 60 days

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