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2022 Oct 23;27(21):7167

Oral administration: 0.5-1 mg daily to compensate for lower bioavailability compared to injection

10.1016/S0033-0620(97)80037-0

This decreases the darker eumelanin and increases the lighter pheomelanin, leading to a lighter and fairer skin tone

eumelanin offers better UV protection Proliferation of melanocytes in long-term exposure Skin darkening (= tanning without UV) This mechanism is why Melanotan II causes visible skin pigmentation already after a few doses

Pathophysiology The pathophysiology of CVS is yet to be established although several potential underlying mechanisms have been postulated