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The retatrutide dose schedule still recommends starting at a conservative dose to assess tolerance of the glucagon component, even if you were on high-dose tirzepatide previously
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Safe GLP-1 therapy generally requires: Baseline metabolic laboratory testing Medication review Screening for thyroid and pancreatic history Ongoing clinical follow-up Lowering the dose does not eliminate contraindications
Another phase 2 RCT studying semglutide 2.4 mg vs placebo in patients with compensated NASH cirrhosis did not show any statistically significant difference in NASH resolution or improvement in liver fibrosis between the groups
AGE, 34(3), 563-570
