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Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity

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Recent investigations further indicated that UA may operate as a protective factor mediated through astroglia for dopaminergic neurons from glutamate toxicity ( + -induced depolarization amplifies neuroprotection provided by UA through a mechanism involving Ca 2 elevation and extracellular signal-regulated kinases (ERK 1/2 ) activation ( Figure 3 )

Neuroimaging, biofluid analysis, and histopathology methods can all be used to accomplish this thorough assessment

doi:10.1093/jn/133.5.1291 Olthof MR, Verhoef P