Clinical trials with GLP-1 receptor agonists consistently demonstrate significant weight loss, with higher doses (such as semaglutide 2.4 mg weekly) producing approximately 15% average weight loss in adults without diabetes in clinical trials (somewhat less in type 2 diabetes) when combined with lifestyle modification
Methods This was a register-based cross-sectional study including all inhabitants in Region Stockholm, Sweden, who were dispensed a GLP-1 RA between 2019 and 2023
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Moreover, the inhibitory effects of chronic systemic liraglutide on food intake and body weight are blunted with blockade of central 5-HT 2A receptors [109]