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Free fatty acids increase in circulation
Foley, R
At the end of the study, final blood samples were taken, and the animals were euthanized by cardiac injection
Studies in aged rats show that mitochondrial membrane potential, cardiolipin content, respiratory control ratio, and cellular oxygen uptake are significantly reduced compared to young animals, while oxidative stress markers are elevated
Across clinical trials and real-world settings, weight loss remained modest, relapse rates after discontinuation were high, and treatment was often fragmented, lacking integration into interdisciplinary care models
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