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A drug that activates this receptor alongside GLP-1 and GIP must balance those effects carefully
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Unlike older weight-loss medications, tirzepatide's dual-receptor mechanism works on multiple hunger pathways simultaneously, which explains why it outperforms single-receptor GLP-1 drugs like semaglutide in head-to-head trials
10.1111/j.1460-9568.2008.06099.x 68
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