Understanding how these medications work is essential context for evaluating their potential effects on bone health, as both their metabolic actions and the weight loss they induce may theoretically influence bone density and skeletal integrity
This highlights the potential use of semaglutide due to its low cost and superior performance
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Mean weight loss was 15.3 kg (33.7 lb) among teens on semaglutide, while those on placebo gained 2.4 kg (5.3 lb). Based on this data, Wegovy is now FDA-approved in kids ages 12-17
While metformin and lifestyle modification are the preferred first-line treatments in patients with T2DM and an elevated HbA1c, GLP-1 RAs are now a preferred second-line therapy and are even recommended first-line agents in patients with known atherosclerotic cardiovascular disease, high cardiovascular risk, or chronic kidney disease
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