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All these measurements were performed on an aberration-corrected FEI Titan electron microscope operating at 300 kV equipped with a FEG cathode

However, when ROS production increases in pathological conditions, it creates an imbalance between prooxidants and antioxidants in the skin and the blood [3]

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As evident from the structures, arr1 binding to SH3 RT loop and the 3 10 helix disrupts the clamp mechanism of Src autoinhibition and releases the SH2SH1 linker and the SH1 domain (Fig