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Severe diarrhea (six or more watery stools in 24 hours) within two days of the first dose is uncommon but not dangerous
The review revisited SUSTAIN-6, where semaglutide-treated patients showed a hazard ratio of 1.76 for retinopathy complications compared with placebo. The discussion has since shifted toward whether rapid metabolic changerather than direct retinal toxicitymay explain the signal
Kosanovic T, Sagic D, Djukic V, Pljesa-Ercegovac M, Savic-Radojevic A, Bukumiric Z et al
It simply decreases your appetite
Weekly doses of tirzepatide are generally higher than the maximum once-weekly semaglutide doses
This can make you feel less hungry and satisfied with smaller portions
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