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FOXO4-DRI theoretically has higher selectivity by targeting the FOXO4-p53 interaction that is specifically elevated in senescent cells

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While the majority of published data originates from the Sikiric laboratory in Zagreb, independent groups have increasingly contributed to the literature, and the peptide remains a subject of active investigation across multiple areas of preclinical science.

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Most evidence preclinical

Villarroya, F., Peyrou, M