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Shorter stability post-reconstitution: The peptide should be refrigerated and used promptly to preserve potency

However, individuals with Wilsons disease or copper metabolism disorders should exercise extreme caution

10.1007/s00109-016-1488-y 28 IlicS.BrcicI.MesterM.FilipovicM.SeverM.KlicekR.et al (2009)

A GP or specialist can assess whether an individual's medical history, current medications, or underlying conditions make the use of a GLP-1/GIP/glucagon receptor agonist particularly risky

The key principle is identifying and managing any significant underlying pathology

With histamine intolerance, there could either be a genetic or a simple impairment in either or both of the enzymes responsible for the histamine breakdown leading to histamine build-up