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T2DM is characterized by the presence of chronic fluctuating hyperglycemia, obesity-associated insulin resistance as well as the impaired secretion of insulin and dysfunction of the incretin system
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GLP-1 RAs have also been shown to have a negative impact on colonoscopy procedures by significantly lowering the quality of bowel preparation
According to Drucker the findings, published in December 2023, provided the first demonstration of 'a GLP-1-brain-immune axis that controls inflammation across the body independent of weight loss, even in peripheral organs devoid of GLP1 receptors.' Drucker's team has not yet identified which particular brain cells interact with GLP-1 (AAAS)