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To minimise discomfort, healthcare professionals recommend gradual dose escalation, also known as titration, which allows the body to adjust to the medication in a stepwise manner
Therapy should be evaluated and lab work should be reviewed to see what the levels are, determine if the levels are low, determine if the levels are rising appropriately with therapy, and assure that this therapy is having an effect and is needed and useful
Notably, exenatide displayed the longest median onset time for cholecystitis and cholelithiasis in patients under 18 years old, at 451 days, while tirzepatide had the shortest median onset time in patients over 65 years old, at 55 days
A prospective cohort study compared the effect of metformin as monotherapy versus metformin with additional therapy of either insulin or GLP-1 RA on lung function in 32 non-asthmatic patients with T2D over 2 years [99]
Retatrutide appeared to have less of a weight loss ceiling meaning weight loss continued longer, without as much early plateauing
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