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Cardiovascular side effects with semaglutide are generally mild, and the SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events (MACE) in people with established heart disease
Eisenberg T, Knauer H, Schauer A, Bttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Frhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009) Induction of autophagy by spermidine promotes longevity
Adherence also plays a critical role
The difference between semaglutide, tirzepatide, and retatrutide comes down to how many of those signals theyre influencing at the same time
The research has been published in the New England Journal of Medicine .
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