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Next, the irreversible transfer of a methyl group from SAM to GAA is catalysed by the enzyme SAM:guanidinoacetate N -methyltransferase ( Reference Wyss and Kaddurah-Daouk 17 )

Zinc, along with other trace elements like copper and nickel, enhances neutrophil chemotaxis, promoting their migration to sites of infection in a manner similar to the chemotactic factor N-formylmethionyl-leucyl-phenylalanine (fMLP)

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