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Part of that effect happens in the brain
Y.et al
21 Filina AA, Davydova NG, Endrikhovskii SN, Shamshinova AM
N Engl J Med 358(6):580591 Garvey WT, Van Gaal L, Leiter LA, Vijapurkar U, List J, Cuddihy R et al (2018) Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes
n= 2851) as add-on therapy to metformin (85% of individuals) and/or sulfonylureas (74% of individuals) showed that GLP-1RA combination therapy was associated with a lower risk of MACE (HR 0.64 [95% CI 0.43, 0.97]) and all-cause death (HR 0.53 [95% CI 0.35, 0.79]) compared with DPP4i, but not with SGLT2i
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