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A scheme of the main effects on the glutamatergic system observed in GA1 is shown in Fig
The following represents a theoretical ultra-conservative approach based on monotherapy principles: Hypothetical Ultra-Conservative Schedule: This extended 24-week titration period doubles the typical monotherapy escalation timeline , reflecting the complete absence of interaction data and the overlapping side effect profiles
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Early brain injury alters the blood-brain barrier phenotype in parallel with -amyloid and cognitive changes in adulthood
This shift results in increased production of mitochondrial ROS, which in turn activates the NLRP3 inflammatory pathway, ultimately leading to inflammation and apoptosis in the kidney [46, 47]
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