The presence of large senescent cells in the kidney marrow of aged killifish recapitulates a conserved senescence-specific feature previously identified in budding yeast and mammalian cells 61,62
doi: 10.3389/fmedt.2025.1654003 Received 25 June 2025 Accepted 20 October 2025 Published 20 November 2025 Volume 7 - 2025 Edited by Barkha Yadav-Samudrala, University of North Carolina at Chapel Hill, United States Reviewed by Sadanand Pandey, Yeungnam University, Republic of Korea Deepak Kumar Tripathi, University of Colorado Anschutz Medical Campus, United States Updates Copyright 2025 Kumar, Sharma and Singh
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Nutrients , 9(5), 429
For example, early inhibition of IL-1 secreted by macrophages in acute myocardial infarction leads to insufficient scar formation and cardiac rupture (330), whereas early inhibition of IL-1 in ischemia-reperfusion injury can reduce infarct size and improve ventricular remodeling (331)