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Most of the medication is processed through safe pathways known as sulfation and glucuronidation

Steinert EM, Vasan K, Chandel NS

Once-weekly dulaglutide for the treatment of youths with type 2 diabetes

While taking Semaglutide GLP-1, essentially suppresses appetite through GLP-1 receptor antagonists binding GLOP-1 receptors in the brain

Many people continue with maintenance doses (once weekly or monthly) indefinitely to sustain results

The frequency of these side effects, as well as the high cost of the medications, have been identified as factors that can discourage people from continuing to take the drugs, which may then result in weight regain